5e Diseases

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Please leave the "(5e Disease)" identifier in the page title when creating your new disease!


See Also: 5e Diseases

Diseases Summary
Abyssal Flames Your soul is being consumed
Acid Plague A infection of sores that contain acid
Alkali Fever If the air smells of metal, run.
Arachnomania And you thought the Drider was the most monstrous spider out there?
Assassin's Spit A common poison used to kill people from the distance of a blowgun.
Betraying Blessing A blessing which is not what it seems. Causes negative effects soon after catching.
Black Fly Filth Fever A disease spread by flies that causes the afflicted to slowly rot
Bleeding Swords don't just hurt you, silly! They make you BLEED!
Dance Fever A sickness that causes those afflicted to dance uncontrollably
Dead Frog Disease This disease is a deadly disease only found in wet tombs or deep in sewers
Dire Diseases!
Flame Venom Avoid the Dragon's tooth.
Form Reconstruction A disease which causes infected to melt and spread the disease to others.
Glitched The channeling of ones Ḡ̯͍̣̠̩̇̒̀̊ͅl͍̖̝ͨ͗̏i̜̦̗̇ͤ̎͌͌̎t̤̣ͨͨ̔̄̀̓̂c̭̖ͣ̇͒ͥͦh̐ͦ̏ into another host.
Hanahaki Disease Please...love me back...
Impassioned Perception Sense the emotions of others around you
Infected Heart A disease which spreads infection through heartbeats.
Ligma A rare disease often affecting Fornite streamers.
Miners Plague Miners Plague is a disease that comes from mushrooms from the Underdark or similar locations. The Miners Plague slowly infects the host until it forms sacks of pollen on it then taking over its mind it and makes the target explode in a populated area killing the host and spreading the Plague.
Morph Fever A disease coming across from overuse of polymorph or from other magic sources.
Necrotic Disease A death dog is deadly indeed; one bite is all they need.
Nyctodiafora You ain’t seen nothin’ yet, son!
Otug's Disease A disease which afflicts you with mindless, uncontrollable rage.
Plague of Thorns, Variant Grow spikes, lose your hands
Radiation Poisoning Sickness and afflictions caused by exposure to radiation.
Random Change
Rigor Vitalis A disease which causes bodily stiffness in the living.
Rotscale Flaky skin and an infection of the eyes can turn one into the stuff of nightmares.
Sailor's Strait You'll be dying, you'll be crying, early in the morning.
Scale Sickness/Dragon Lycanthropy This is much less awesome than it sounds, I promise.
Shadowflame Corruption The disease cannot be contracted by a player, but it can be contracted by monsters and NPCs.
Shivers Disease Shivers Disease is a common disease that makes the host sick with extreme vomiting,Heat sweats and Uncontrollable shivering. This disease spreads to other's through sweat.
Shrinking Sickness Spread by certain animals and plants to protect themselves.
Silent Screams Nobody can hear your suffering if you can't even speak.
Singing Madness You can't stop singing.
Snow Sickness The bane of travelers in the coldest regions.
Spawn This will let you find your center.
Stoneheart You feel your blood begin to thicken, and your body becomes hard to move...
The Plague A slow and painful death.
The Soups Have you ever had the displeasure of soup projecting out of both ends just because you got a little spooked?
Transformational Plague You start transforming into other creatures you've touched.
Useful Adventurer A disease causing creatures to become unnaturally (and painfully) useful.
Walter's Syndrome A strange disease that makes you speak in a constantly angry tone.
Weaver's Fever A flu-like disease. Annoying, but not lethal... unless you're a wizard.
Werepyre Curse This is what happens when a victim gets bit by a werewolf and vampire, both.
Wonky Body The afflicted’s body changes randomly, and becomes extremely awkward and possibly debilitating.
Zombie Virus Get bit by a zombie, become a zombie

Back to Main Page5e Homebrew

Please leave the "(5e Curse)" identifier in the page title when creating your new curse!


For when you want something a little more supernatural, that your paladins can be afflicted with

Curses Summary
A Day in Seven Lives Turns you into a completely different person each day for seven days.
Bad Juju A curse that makes the "infected" clumsy and have bad luck.
Baneweaver Curse Something made mother nature mad. You should probably find out what.
Begger's Curse of the Sea For that one player who keeps asking to fight stuff.
Broken Halo A curse placed on a high priest or paladin for acting against their god's will.
Curse of Incompetence Reduce your proficiency score!
Curse of the River Goddess A dehydrating curse created by a spiteful river goddess.
Fiend Fever *not actually a fever
Greed’s Death, Variant Cough up gold! Could be fatal...
Nature's Rage May you engage in brutal combat
Ragnarok Mark You are now virtual property of the gods upon your end
Sacrosanct Those who stand by the sword shall die by it.
Sinister Sleepwalking
Teleglow The matter in your body doesn't want to stay there, and the things that shouldn't be there suddenly are
The Adventuring Curse A curse designed to make Shawn Spellblade unstoppable. Not that he cared to be.
Trumpet's Bane Trumpets sound nice normally, right?
VIRUS The power to make a deity despair by sealing their power... That is VIRUS.
Witch's Curse Fly, my pretties! Fly!
Wooden Fingers

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