Discussion:Can large weapons be wielded in one hand?
From D&D Wiki
 Can large weapons be wielded in one hand?
 No problem 17:47, 3 March 2008 (MST)
can one wield a two handed weapon in one hand? if so, what are the penalties and are they less if one has high strength or dexterity?
Hold a two handed weapon in one hand? Sure. Attack with one? Not really, it's improvised then, -4 and all, since you're not supposed to use say, a Greatsword one-handed and expect to still be useful swinging it.
 No problem 04:33, 4 March 2008 (MST)
i would still expect a really strong character to be able to wield it as effectively as he would a longsword.
It'll have to be houseruled in. But I don't recommend this, if only from a game balance standpoint. If characters who are strong are able to duel wield greatswords, who would ever want to use a light or one handed weapon again? But I believe it is the feat Monkey Grip which actually provides you with what you seek (and the Improved Monkey Grip on this Wiki here) which would allow what you say at -2 (no getting around the penalty, for the same reason I suspect no getting around the Two Weapon Fighting penalty, game balance). Plus if you wanted, you could use a two handed Large Greatsword too.
Also, even if one is theoretically strong enough, using a dispropotianally sized weapon is just going to be clumsy. Weapons are designed in proportion to an average person's arm length, hand size, etc.
If you want to be able to use a 2 handed weapon 1 handed take Monkey Grip.
 123098zxcmnb 18:21, 14 May 2008 (MDT)
On the topic of strength, a large strength bonus counteracts the penalty and it still is harder for a strong character to wield a large weapon than it is to wield a stronger one.